InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNK2

Summary

InnateDB Protein

IDBP-386989.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNK2

Protein Name

tyrosine kinase, non-receptor, 2

Synonyms

ACK; ACK-1; ACK1; p21cdc42Hs;

Species

Homo sapiens

Ensembl Protein

ENSP00000392546

InnateDB Gene

IDBG-70926 (TNK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	88 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR015116 Cdc42 binding domain like
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021619 EGFR receptor inhibitor Mig-6

PFAM

PF00069
PF07714
PF00018
PF14604
PF09027
PF11555

PRINTS

PR00109
PR00452

PIRSF

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt