InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP7

Summary

InnateDB Protein

IDBP-387023.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP7

Protein Name

A kinase (PRKA) anchor protein 7

Synonyms

AKAP15; AKAP18;

Species

Homo sapiens

Ensembl Protein

ENSP00000405252

InnateDB Gene

IDBG-96473 (AKAP7)

Protein Structure

UniProt Annotation

Function

Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. {ECO:0000269PubMed:10613906, ECO:0000269PubMed:17244820}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:10613906}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, lung, pancreas and placenta. {ECO:0000269PubMed:10613906}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0051018	protein kinase A binding

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase
IPR019510 Protein kinase A anchor protein, nuclear localisation signal domain
IPR019511 Protein kinase A anchor protein, RI-RII subunit-binding domain

PFAM

PF10469
PF10470

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P0M2

PhosphoSite