Version 5.4
Homo sapiens Protein: SYCE1
Summary
InnateDB Protein IDBP-387181.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYCE1
Protein Name synaptonemal complex central element protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000411779
InnateDB Gene IDBG-93867 (SYCE1)
Protein Structure
UniProt Annotation
Function Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Chromosome. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007130 synaptonemal complex assembly
Cellular Component
GO:0000801 central element
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N0S2
PhosphoSite PhosphoSite-Q8N0S2
TrEMBL
UniProt Splice Variant
Entrez Gene 93426
UniGene Hs.553795
RefSeq
HUGO HGNC:28852
OMIM 611486
CCDS
HPRD 12598
IMGT
EMBL AK314978 AL161645 AY027807 AY027808 AY028079 BC034821 CH471211
GenPept AAH34821 AAK14796 AAK14797 AAK21976 BAG37477 CAH70048 EAW61359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca