InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLG1

Summary

InnateDB Protein

IDBP-387200.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG1

Protein Name

discs, large homolog 1 (Drosophila)

Synonyms

dJ1061C18.1.1; DLGH1; hdlg; SAP-97; SAP97;

Species

Homo sapiens

Ensembl Protein

ENSP00000398939

InnateDB Gene

IDBG-71508 (DLG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008092	cytoskeletal protein binding
GO:0015459	potassium channel regulator activity
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0044325	ion channel binding
GO:0097016	L27 domain binding

Biological Process

GO:0001935	endothelial cell proliferation
GO:0007015	actin filament organization
GO:0007093	mitotic cell cycle checkpoint
GO:0007163	establishment or maintenance of cell polarity
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0016032	viral process
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030866	cortical actin cytoskeleton organization
GO:0042391	regulation of membrane potential
GO:0043268	positive regulation of potassium ion transport
GO:0045930	negative regulation of mitotic cell cycle
GO:0046939	nucleotide phosphorylation
GO:0070830	tight junction assembly
GO:0072659	protein localization to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009898	cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0014704	intercalated disc
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0042383	sarcolemma
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097025	MPP7-DLG1-LIN7 complex

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR016313 Disks large 1
IPR019583 PDZ-associated domain of NMDA receptors
IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM