Version 5.4
Homo sapiens Protein: FYTTD1
Summary
InnateDB Protein IDBP-387266.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FYTTD1
Protein Name forty-two-three domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000394631
InnateDB Gene IDBG-71774 (FYTTD1)
Protein Structure
UniProt Annotation
Function Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269PubMed:19836239}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:19836239}. Nucleus speckle {ECO:0000269PubMed:19836239}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006406 mRNA export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR009782 Protein of unknown function DUF1346
PFAM PF07078
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96QD9
PhosphoSite PhosphoSite-Q96QD9
TrEMBL H9KVC6
UniProt Splice Variant
Entrez Gene 84248
UniGene Hs.602541
RefSeq
HUGO HGNC:25407
OMIM
CCDS
HPRD 10909
IMGT
EMBL AC024560 AC055764 AJ344094 AK027672 AK296283 AK302546 AK303462 AK315019 AK316308 AL136558 BC035006 BC039734 CH471252 CR533502
GenPept AAH35006 AAH39734 BAB55284 BAG37509 BAH12300 BAH13737 BAH13966 BAH14679 CAB66493 CAC51432 CAG38533 EAW92240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca