InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNH2

Summary

InnateDB Protein

IDBP-387334.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH2

Protein Name

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonyms

ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000387657

InnateDB Gene

IDBG-48331 (KCNH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005242	inward rectifier potassium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0003064	regulation of heart rate by hormone
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0023014	signal transduction by phosphorylation
GO:0035690	cellular response to drug
GO:0042391	regulation of membrane potential
GO:0055075	potassium ion homeostasis
GO:0055085	transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0060306	regulation of membrane repolarization
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086010	membrane depolarization during action potential
GO:0086011	membrane repolarization during action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901379	regulation of potassium ion transmembrane transport
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:1901381	positive regulation of potassium ion transmembrane transport
GO:1902303	negative regulation of potassium ion export

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0009986	cell surface
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR000595 Cyclic nucleotide-binding domain
IPR000700 PAS-associated, C-terminal
IPR001610 PAC motif
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003967 Potassium channel, voltage-dependent, ERG
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF13188
PF13426
PF00027
PF00520
PF07885

PRINTS

PR01463
PR01470

PIRSF

SMART

SM00091
SM00100
SM00086

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt