InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBR3

Summary

InnateDB Protein

IDBP-387383.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBR3

Protein Name

ubiquitin protein ligase E3 component n-recognin 3 (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000396068

InnateDB Gene

IDBG-74617 (UBR3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001967	suckling behavior
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007608	sensory perception of smell
GO:0009790	embryo development
GO:0016567	protein ubiquitination
GO:0042048	olfactory behavior