Version 5.4
Homo sapiens Protein: GALNTL5
Summary
InnateDB Protein IDBP-387423.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GALNTL5
Protein Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392582
InnateDB Gene IDBG-49733 (GALNTL5)
Protein Structure
UniProt Annotation
Function Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.
Subcellular Localization Late endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). {ECO:0000250}.
Disease Associations Note=Defects in GALNTL5 have been found in a patient with primary infertility due to asthenozoospermia. {ECO:0000269PubMed:24398516}.
Tissue Specificity Mainly expressed in testis. Weakly or not expressed in other tissues. {ECO:0000269PubMed:24398516}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0007286 spermatid development
Cellular Component
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4T8
PhosphoSite PhosphoSite-Q7Z4T8
TrEMBL
UniProt Splice Variant
Entrez Gene 168391
UniGene Hs.647077
RefSeq XP_006715926
HUGO HGNC:21725
OMIM 615133
CCDS CCDS5929
HPRD 13565
IMGT
EMBL AC006017 AC074257 AC099345 AF440400 AF440404 BC022021
GenPept AAD45823 AAH22021 AAM20912 AAP97318 AAS07428 AAS07457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca