InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALNT11

Summary

InnateDB Protein

IDBP-387444.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT11

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410093

InnateDB Gene

IDBG-49749 (GALNT11)

Protein Structure

UniProt Annotation

Function

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269PubMed:11925450, ECO:0000269PubMed:24226769}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:11925450}; Single-pass type II membrane protein {ECO:0000269PubMed:11925450}.

Disease Associations

Note=Defects in GALNT11 may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left- right (LR) body patterning. {ECO:0000269PubMed:21282601}.

Tissue Specificity

Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli. {ECO:0000269PubMed:11925450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005112	Notch binding
GO:0046872	metal ion binding

Biological Process

GO:0007220	Notch receptor processing
GO:0007368	determination of left/right symmetry
GO:0008593	regulation of Notch signaling pathway
GO:0016266	O-glycan processing
GO:0018243	protein O-linked glycosylation via threonine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0060271	cilium morphogenesis
GO:0061314	Notch signaling involved in heart development