Version 5.4
Homo sapiens Protein: REPS1
Summary
InnateDB Protein IDBP-387523.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REPS1
Protein Name RALBP1 associated Eps domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392065
InnateDB Gene IDBG-97100 (REPS1)
Protein Structure
UniProt Annotation
Function May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Subcellular Localization Membrane, clathrin-coated pit {ECO:0000269PubMed:20946875}. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin- coated pits.
Disease Associations
Tissue Specificity Widely expressed with highest levels in heart and testis. {ECO:0000269PubMed:11750063}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006898 receptor-mediated endocytosis
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
Protein Structure and Domains
PDB ID
InterPro IPR000261 EPS15 homology (EH)
IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00027
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96D71
PhosphoSite PhosphoSite-Q96D71
TrEMBL
UniProt Splice Variant
Entrez Gene 85021
UniGene Hs.732041
RefSeq NP_001273540
HUGO HGNC:15578
OMIM 614825
CCDS CCDS69213
HPRD 09687
IMGT
EMBL AF251052 AL121834 AL590308 AL591033 AL831900 AL832307 BC012764 BC021211 CH471051 DB263697
GenPept AAH12764 AAH21211 AAK34942 CAD38569 CAI42877 CAI42878 CAI42879 CAX15096 CAX15097 CAX15098 EAW47904 EAW47906 EAW47907

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca