InnateDB Protein
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IDBP-387745.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MOV10
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Protein Name
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Mov10, Moloney leukemia virus 10, homolog (mouse)
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Synonyms
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fSAP113; gb110;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000399797
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InnateDB Gene
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IDBG-101151 (MOV10)
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Protein Structure
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Function |
Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269PubMed:16289642, ECO:0000269PubMed:17507929, ECO:0000269PubMed:18552826, ECO:0000269PubMed:22791714}.
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Subcellular Localization |
Cytoplasm, P-body {ECO:0000269PubMed:16289642}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
72
[view]
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Protein-Protein |
71
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0007219
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Notch signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0035279
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mRNA cleavage involved in gene silencing by miRNA
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HCE1
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PhosphoSite |
PhosphoSite-Q9HCE1
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TrEMBL |
Q5JR04
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UniProt Splice Variant |
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Entrez Gene |
4343
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UniGene |
Hs.706697
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RefSeq |
NP_066014
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HUGO |
HGNC:7200
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OMIM |
610742
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CCDS |
CCDS853
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HPRD |
14732
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IMGT |
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EMBL |
AB046851
AK057353
AK074174
AL603832
AL833353
BC002548
BC004499
BC009312
CH471122
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GenPept |
AAH02548
AAH04499
AAH09312
BAB13457
BAB85000
BAG51905
CAI14055
EAW56528
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