InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SESTD1

Summary

InnateDB Protein

IDBP-387854.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SESTD1

Protein Name

SEC14 and spectrin domains 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000415332

InnateDB Gene

IDBG-76589 (SESTD1)

Protein Structure

UniProt Annotation

Function

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. {ECO:0000269PubMed:20164195}.

Subcellular Localization

Disease Associations

Tissue Specificity

Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature. {ECO:0000269PubMed:20164195}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0070300	phosphatidic acid binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding