InnateDB Protein
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IDBP-388099.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NABP1
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Protein Name
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oligonucleotide/oligosaccharide-binding fold containing 2A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403683
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InnateDB Gene
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IDBG-77673 (NABP1)
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Protein Structure
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Function |
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004365
OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR012340
Nucleic acid-binding, OB-fold
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PFAM |
PF01336
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96AH0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64859
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UniGene |
Hs.591610
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RefSeq |
NP_001026886
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HUGO |
HGNC:26232
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OMIM |
612103
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CCDS |
CCDS33352
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HPRD |
08009
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IMGT |
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EMBL |
AC114778
AK026486
AL832659
BC017114
BC107723
CH471058
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GenPept |
AAH17114
AAI07724
AAY24348
BAB15491
CAH56209
EAX10836
EAX10837
EAX10838
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