InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHD1L

Summary

InnateDB Protein

IDBP-388168.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD1L

Protein Name

chromodomain helicase DNA binding protein 1-like

Synonyms

ALC1; CHDL;

Species

Homo sapiens

Ensembl Protein

ENSP00000389031

InnateDB Gene

IDBG-101816 (CHD1L)

Protein Structure

UniProt Annotation

Function

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. {ECO:0000269PubMed:18023026, ECO:0000269PubMed:19661379}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19661379}. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.

Disease Associations

Tissue Specificity

Frequently overexpressed in hepatomacellular carcinomas. {ECO:0000269PubMed:18023026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006974	cellular response to DNA damage stimulus
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR002589 Macro domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021006 Histone deacetylase complex, subunit 2/3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF01661
PF11496

PRINTS

PIRSF

SMART

SM00490
SM00506
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86WJ1