InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMF1

Summary

InnateDB Protein

IDBP-38821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMF1

Protein Name

proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

Synonyms

PI31;

Species

Homo sapiens

Ensembl Protein

ENSP00000327704

InnateDB Gene

IDBG-38819 (PSMF1)

Protein Structure

UniProt Annotation

Function

Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269PubMed:10764772}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18495667}. Endoplasmic reticulum {ECO:0000269PubMed:18495667}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0070628	proteasome binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0010951	negative regulation of endopeptidase activity
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:1901799	negative regulation of proteasomal protein catabolic process