Version 5.4
Homo sapiens Protein: CASP8
Summary
InnateDB Protein IDBP-388335.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP8
Protein Name caspase 8, apoptosis-related cysteine peptidase
Synonyms ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5;
Species Homo sapiens
Ensembl Protein ENSP00000390641
InnateDB Gene IDBG-78534 (CASP8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 219 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 219 [view]
Protein-Protein 208 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001875 Death effector domain
IPR011029 Death-like domain
PFAM PF01335
PRINTS
PIRSF
SMART SM00031
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E7EQ01
UniProt Splice Variant
Entrez Gene 841
UniGene Hs.715120
RefSeq
HUGO HGNC:1509
OMIM 601763
CCDS
HPRD 03459
IMGT
EMBL AC007256 AC007283
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca