Version 5.4
Homo sapiens Protein: NSRP1
Summary
InnateDB Protein IDBP-38843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSRP1
Protein Name nuclear speckle splicing regulatory protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000247026
InnateDB Gene IDBG-38841 (NSRP1)
Protein Structure
UniProt Annotation
Function RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269PubMed:21296756}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21296756}. Nucleus speckle {ECO:0000269PubMed:21296756}. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.
Disease Associations
Tissue Specificity Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes. {ECO:0000269PubMed:21296756}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006913 nucleocytoplasmic transport
GO:0008380 RNA splicing
GO:0032502 developmental process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR018612 Domain of unknown function DUF2040
PFAM PF09745
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0G5
PhosphoSite PhosphoSite-Q9H0G5
TrEMBL K7ERM9
UniProt Splice Variant
Entrez Gene 84081
UniGene Hs.609627
RefSeq NP_115517
HUGO HGNC:25305
OMIM
CCDS CCDS11255
HPRD 08536
IMGT
EMBL AC104984 AL136806 BC040118 BC105044 BC105046 CH471159 CR533555
GenPept AAH40118 AAI05045 AAI05047 CAB66740 CAG38586 EAW51220 EAW51222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca