Version 5.4
Homo sapiens Protein: RAPH1
Summary
InnateDB Protein IDBP-388501.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPH1
Protein Name Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406662
InnateDB Gene IDBG-79104 (RAPH1)
Protein Structure
UniProt Annotation
Function Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15469845}; Peripheral membrane protein {ECO:0000269PubMed:15469845}; Cytoplasmic side {ECO:0000269PubMed:15469845}. Cell projection, lamellipodium {ECO:0000269PubMed:15469845}. Cell projection, filopodium {ECO:0000269PubMed:15469845}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15469845}. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
Disease Associations
Tissue Specificity Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. {ECO:0000269PubMed:15469845, ECO:0000269PubMed:15609301}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR001849 Pleckstrin homology domain
IPR029071 Ubiquitin-related domain
PFAM PF00788
PF00169
PRINTS
PIRSF
SMART SM00314
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q70E73
PhosphoSite PhosphoSite-Q70E73
TrEMBL C9JLG4
UniProt Splice Variant
Entrez Gene 65059
UniGene Hs.694570
RefSeq
HUGO HGNC:14436
OMIM 609035
CCDS
HPRD 12356
IMGT
EMBL AB051468 AB053311 AC018891 AJ584699 AY494951 AY523977 AY523978
GenPept AAS16935 AAS16936 AAS82582 AAY14676 BAB21772 BAB69020 CAE48361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca