InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD28

Summary

InnateDB Protein

IDBP-388507.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD28

Protein Name

CD28 molecule

Synonyms

Tp44;

Species

Homo sapiens

Ensembl Protein

ENSP00000393648

InnateDB Gene

IDBG-79183 (CD28)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0042802	identical protein binding

Biological Process

GO:0006959	humoral immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042089	cytokine biosynthetic process
GO:0042102	positive regulation of T cell proliferation
GO:0045066	regulatory T cell differentiation
GO:0045070	positive regulation of viral genome replication
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045727	positive regulation of translation
GO:0045840	positive regulation of mitosis
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050690	regulation of defense response to virus by virus