InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFA5

Summary

InnateDB Protein

IDBP-38853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA5

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa

Synonyms

B13; CI-13kB; CI-13KD-B; NUFM; UQOR13;

Species

Homo sapiens

Ensembl Protein

ENSP00000347988

InnateDB Gene

IDBG-38849 (NDUFA5)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Disease Associations

Tissue Specificity

Expressed in all tissues examined with highest levels in heart, skeletal muscle and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process