InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR1

Summary

InnateDB Protein

IDBP-388567.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR1

Protein Name

G protein-coupled receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000397535

InnateDB Gene

IDBG-79470 (GPR1)

Protein Structure

UniProt Annotation

Function

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1. {ECO:0000269PubMed:18165312}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in hippocampus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186

G-protein coupled receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002275 G protein-coupled receptor 1 orphan
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00241
PR00237
PR01146

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46091