InnateDB Protein
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IDBP-388615.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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METTL21A
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Protein Name
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methyltransferase like 21A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389684
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InnateDB Gene
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IDBG-79590 (METTL21A)
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Protein Structure
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Function |
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys- 564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys- 561' in HSPA8. {ECO:0000269PubMed:22948820, ECO:0000269PubMed:23349634, ECO:0000269PubMed:23921388}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:23349634}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019410
Nicotinamide N-methyltransferase-like
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF10294
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WXB1
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PhosphoSite |
PhosphoSite-Q8WXB1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
151194
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UniGene |
Hs.664764
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RefSeq |
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HUGO |
HGNC:30476
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OMIM |
615257
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CCDS |
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HPRD |
14090
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IMGT |
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EMBL |
AC079767
AF455817
AK093812
BC009462
BC033720
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GenPept |
AAH09462
AAH33720
AAL66295
AAX93175
BAC04229
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