InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPS1

Summary

InnateDB Protein

IDBP-388714.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPS1

Protein Name

carbamoyl-phosphate synthase 1, mitochondrial

Synonyms

CPSASE1; PHN;

Species

Homo sapiens

Ensembl Protein

ENSP00000402608

InnateDB Gene

IDBG-79973 (CPS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004087	carbamoyl-phosphate synthase (ammonia) activity
GO:0004175	endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016595	glutamate binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0072341	modified amino acid binding

Biological Process

GO:0000050	urea cycle
GO:0001101	response to acid
GO:0001889	liver development
GO:0005980	glycogen catabolic process
GO:0006508	proteolysis
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007494	midgut development
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0010043	response to zinc ion
GO:0014075	response to amine
GO:0019240	citrulline biosynthetic process
GO:0019433	triglyceride catabolic process
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0033762	response to glucagon
GO:0034201	response to oleic acid
GO:0034641	cellular nitrogen compound metabolic process
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043200	response to amino acid
GO:0044281	small molecule metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045909	positive regulation of vasodilation
GO:0046209	nitric oxide metabolic process
GO:0048545	response to steroid hormone
GO:0050667	homocysteine metabolic process
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0055081	anion homeostasis
GO:0060416	response to growth hormone
GO:0070365	hepatocyte differentiation
GO:0070409	carbamoyl phosphate biosynthetic process
GO:0071320	cellular response to cAMP
GO:0071377	cellular response to glucagon stimulus
GO:0071400	cellular response to oleic acid
GO:0071548	response to dexamethasone

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0042645	mitochondrial nucleoid
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
IPR006274 Carbamoyl-phosphate synthase, small subunit
IPR006275 Carbamoyl-phosphate synthase, large subunit
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011607 Methylglyoxal synthase-like domain
IPR011761 ATP-grasp fold
IPR016185 Pre-ATP-grasp domain
IPR017926 Glutamine amidotransferase
IPR029062 Class I glutamine amidotransferase-like

PFAM