Version 5.4
Homo sapiens Protein: ATIC
Summary
InnateDB Protein IDBP-388762.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATIC
Protein Name 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH;
Species Homo sapiens
Ensembl Protein ENSP00000415935
InnateDB Gene IDBG-80213 (ATIC)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003937 IMP cyclohydrolase activity
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002695 AICARFT/IMPCHase bienzyme
IPR011607 Methylglyoxal synthase-like domain
IPR016193 Cytidine deaminase-like
PFAM PF01808
PF02142
PRINTS
PIRSF PIRSF000414
SMART SM00798
SM00851
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31939
PhosphoSite PhosphoSite-P31939
TrEMBL F5GWY2
UniProt Splice Variant
Entrez Gene 471
UniGene Hs.90280
RefSeq
HUGO HGNC:794
OMIM 601731
CCDS
HPRD 03434
IMGT
EMBL AB062403 AC073284 AK290067 BC008879 CH471063 D82348 D89976 U37436
GenPept AAA97405 AAH08879 AAY24062 BAA11559 BAA21762 BAB93490 BAF82756 EAW70529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca