InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX2

Summary

InnateDB Protein

IDBP-38908.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX2

Protein Name

sorting nexin 2

Synonyms

TRG-9;

Species

Homo sapiens

Ensembl Protein

ENSP00000368831

InnateDB Gene

IDBG-38906 (SNX2)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000269PubMed:16179610, ECO:0000269PubMed:17101778}.

Subcellular Localization

Early endosome membrane {ECO:0000269PubMed:16179610, ECO:0000269PubMed:17101778}; Peripheral membrane protein {ECO:0000269PubMed:16179610, ECO:0000269PubMed:17101778}; Cytoplasmic side {ECO:0000269PubMed:16179610, ECO:0000269PubMed:17101778}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006897	endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030904	retromer complex
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome