InnateDB Protein
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IDBP-389510.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2F
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Protein Name
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ubiquitin-conjugating enzyme E2F (putative)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000393515
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InnateDB Gene
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IDBG-84388 (UBE2F)
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Protein Structure
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Function |
Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. {ECO:0000269PubMed:19250909}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed (at protein level). {ECO:0000269PubMed:19250909}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q969M7
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PhosphoSite |
PhosphoSite-Q969M7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
140739
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UniGene |
Hs.625007
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RefSeq |
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HUGO |
HGNC:12480
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OMIM |
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CCDS |
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HPRD |
14812
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IMGT |
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EMBL |
AC016776
AF310723
AK290063
AK293334
AK294107
AK297502
AK303094
BC010549
CH471063
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GenPept |
AAH10549
AAL26792
AAY24220
BAF82752
BAG56850
BAG57442
BAG59915
BAG64204
EAW71129
EAW71132
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