Version 5.4
Homo sapiens Protein: DCAF6
Summary
InnateDB Protein IDBP-389528.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF6
Protein Name DDB1 and CUL4 associated factor 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000396238
InnateDB Gene IDBG-104583 (DCAF6)
Protein Structure
UniProt Annotation
Function Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269PubMed:15784617, ECO:0000269PubMed:16949367, ECO:0000269PubMed:16964240}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15784617}.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland. {ECO:0000269PubMed:15784617}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0016567 protein ubiquitination
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00612
PF00400
PRINTS
PIRSF
SMART SM00015
SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58WW2
PhosphoSite PhosphoSite-Q58WW2
TrEMBL
UniProt Splice Variant
Entrez Gene 55827
UniGene Hs.435741
RefSeq NP_001185886
HUGO HGNC:30002
OMIM 610494
CCDS CCDS55658
HPRD 17156
IMGT
EMBL AF116725 AK297847 AL031287 AL033531 AL033532 AL136738 AY766164 BC025262 CH471067 DQ768089 Z97876
GenPept AAH25262 AAO15301 AAX09330 ABG76793 BAG60180 CAB66672 CAI20078 CAI22478 CAI22481 CAI22625 CAM28213 CAM28292 CAM28293 CAM28303 EAW90809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca