InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: METTL11B

Summary

InnateDB Protein

IDBP-389598.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

METTL11B

Protein Name

methyltransferase like 11B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000408058

InnateDB Gene

IDBG-104746 (METTL11B)

Protein Structure

UniProt Annotation

Function

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. {ECO:0000269PubMed:24090352}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:24090352}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity

Biological Process

GO:0008152	metabolic process
GO:0032259	methylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR008576 Protein of unknown function DUF858, methyltransferase-like
IPR013216 Methyltransferase type 11
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05891
PF08241

PRINTS

PIRSF

PIRSF016958

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VVY1