InnateDB Protein
|
IDBP-3896.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
FAM3B
|
Protein Name
|
family with sequence similarity 3, member B
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000350673
|
InnateDB Gene
|
IDBG-3894 (FAM3B)
|
Protein Structure
|
|
Function |
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. {ECO:0000269PubMed:16114871}.
|
Subcellular Localization |
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. {ECO:0000269PubMed:16114871}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P58499
|
PhosphoSite |
PhosphoSite-P58499
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
54097
|
UniGene |
Hs.736846
|
RefSeq |
NP_478066
|
HUGO |
HGNC:1253
|
OMIM |
608617
|
CCDS |
CCDS13671
|
HPRD |
10552
|
IMGT |
|
EMBL |
AF375989
AF494379
AJ409094
AY040086
AY358459
BC057829
|
GenPept |
AAH57829
AAK74134
AAL34495
AAM94280
AAQ88824
CAC83974
|
|
|