Version 5.4
| Homo sapiens Protein: RNF2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Protein | IDBP-389807.5 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | RNF2 | ||||||||||||||||||||||
| Protein Name | ring finger protein 2 | ||||||||||||||||||||||
| Synonyms | BAP-1; BAP1; DING; HIPI3; RING1B; RING2; | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Protein | ENSP00000400722 | ||||||||||||||||||||||
| InnateDB Gene | IDBG-105369 (RNF2) | ||||||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||||||
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. {ECO:0000269PubMed:11513855, ECO:0000269PubMed:15386022, ECO:0000269PubMed:16359901, ECO:0000269PubMed:16714294, ECO:0000269PubMed:20696397}. | ||||||||||||||||||||||
| Subcellular Localization | Nucleus {ECO:0000269PubMed:21282530}. Chromosome {ECO:0000250}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
| Disease Associations | |||||||||||||||||||||||
| Tissue Specificity | |||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 766 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||||||
| PDB ID | |||||||||||||||||||||||
| InterPro |
IPR001841
Zinc finger, RING-type IPR018957 Zinc finger, C3HC4 RING-type |
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| PFAM |
PF13639
PF14634 PF00097 |
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| PRINTS | |||||||||||||||||||||||
| PIRSF | |||||||||||||||||||||||
| SMART |
SM00184
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| TIGRFAMs | |||||||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||||||
| Modification | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| PhosphoSite | PhosphoSite-Q99496 | ||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 6045 | ||||||||||||||||||||||
| UniGene | Hs.626289 | ||||||||||||||||||||||
| RefSeq | |||||||||||||||||||||||
| HUGO | HGNC:10061 | ||||||||||||||||||||||
| OMIM | 608985 | ||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | 07028 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||