InnateDB Protein
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IDBP-389919.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNRPE
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Protein Name
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small nuclear ribonucleoprotein polypeptide E
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Synonyms
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B-raf; HYPT11; Sm-E; SME;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000400591
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InnateDB Gene
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IDBG-105992 (SNRPE)
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Protein Structure
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Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. {ECO:0000269PubMed:18984161, ECO:0000269PubMed:23246290, ECO:0000269PubMed:23333303}.
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Subcellular Localization |
Cytoplasm, cytosol. Nucleus. Note=SMN- mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
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Disease Associations |
Hypotrichosis 11 (HYPT11) [MIM:615059]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT11 is characterized by scanty or absent eyebrows and a highly variable degree of alopecia since birth, ranging from slight thinning of scalp and axillary hair to complete loss of scalp and body hair. Pubic hair remains mainly unaffected. {ECO:0000269PubMed:23246290}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis. {ECO:0000269PubMed:23246290}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
69
[view]
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Protein-Protein |
69
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
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PFAM |
PF01423
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PRINTS |
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PIRSF |
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SMART |
SM00651
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TIGRFAMs |
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Modification |
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SwissProt |
P62304
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PhosphoSite |
PhosphoSite-P62304
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TrEMBL |
A6NHK2
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UniProt Splice Variant |
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Entrez Gene |
6635
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UniGene |
Hs.654418
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RefSeq |
NP_003085
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HUGO |
HGNC:11161
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OMIM |
128260
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CCDS |
CCDS30979
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HPRD |
00548
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IMGT |
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EMBL |
AC114402
AC118554
AK312130
BC002639
BC090951
CH471067
M15919
M21253
M21258
M37716
X12466
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GenPept |
AAA36621
AAA90926
AAB59365
AAH02639
AAH90951
BAG35066
CAA31007
EAW91494
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