InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDM4

Summary

InnateDB Protein

IDBP-389937.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDM4

Protein Name

Mdm4 p53 binding protein homolog (mouse)

Synonyms

HDMX; MDMX; MRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000396840

InnateDB Gene

IDBG-106054 (MDM4)

Protein Structure

UniProt Annotation

Function

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269PubMed:16163388, ECO:0000269PubMed:16511572}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues tested with high levels in thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	79 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0042177	negative regulation of protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045023	G0 to G1 transition
GO:0050821	protein stabilization
GO:0071157	negative regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia