InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK18

Summary

InnateDB Protein

IDBP-389946.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK18

Protein Name

cyclin-dependent kinase 18

Synonyms

PCTAIRE; PCTAIRE3; PCTK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000399082

InnateDB Gene

IDBG-106143 (CDK18)

Protein Structure

UniProt Annotation

Function

May play a role in signal transduction cascades in terminally differentiated cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 3 expression is limited to several subcortical nuclei of the basal gangli and the spinal cord. Isoform 2 is widely expressed. {ECO:0000269PubMed:15019984}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt