Homo sapiens Protein: RAB7L1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-389953.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | RAB7L1 | ||||||||||||||||||
Protein Name | RAB7, member RAS oncogene family-like 1 | ||||||||||||||||||
Synonyms | RAB7L; RAB7L1; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000389899 | ||||||||||||||||||
InnateDB Gene | IDBG-106171 (RAB7L1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269PubMed:22042847, ECO:0000269PubMed:24788816}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Ubiquitous. {ECO:0000269PubMed:24788816}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001806
Small GTPase superfamily IPR003578 Small GTPase superfamily, Rho type IPR003579 Small GTPase superfamily, Rab type IPR006689 Small GTPase superfamily, ARF/SAR type IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00071
PF00025 PF08477 |
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PRINTS |
PR00449
PR00328 |
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PIRSF | |||||||||||||||||||
SMART |
SM00174
SM00175 SM00173 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | O14966 | ||||||||||||||||||
PhosphoSite | PhosphoSite-O14966 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8934 | ||||||||||||||||||
UniGene | Hs.603513 | ||||||||||||||||||
RefSeq | NP_001129135 | ||||||||||||||||||
HUGO | HGNC:9789 | ||||||||||||||||||
OMIM | 603949 | ||||||||||||||||||
CCDS | CCDS44301 | ||||||||||||||||||
HPRD | 11962 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC119673 AK303879 AK308359 BC002585 D84488 | ||||||||||||||||||
GenPept | AAH02585 BAA22160 BAG64815 | ||||||||||||||||||