Version 5.4
Homo sapiens Protein: FCAMR
Summary
InnateDB Protein IDBP-389972.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCAMR
Protein Name Fc receptor, IgA, IgM, high affinity
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392707
InnateDB Gene IDBG-106298 (FCAMR)
Protein Structure
UniProt Annotation
Function Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. {ECO:0000269PubMed:11779189}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed by mesangial cells. {ECO:0000269PubMed:11779189}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWV6
PhosphoSite PhosphoSite-Q8WWV6
TrEMBL
UniProt Splice Variant
Entrez Gene 83953
UniGene Hs.145519
RefSeq
HUGO HGNC:24692
OMIM 605484
CCDS CCDS41460
HPRD 12020
IMGT
EMBL AF354295 AY063125 AY063126 BC109263 BC109264 E15470
GenPept AAI09264 AAI09265 AAK39522 AAL51154 AAL51155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca