Version 5.4
Homo sapiens Protein: SARNP
Summary
InnateDB Protein IDBP-39103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SARNP
Protein Name SAP domain containing ribonucleoprotein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000337632
InnateDB Gene IDBG-39101 (SARNP)
Protein Structure
UniProt Annotation
Function Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269PubMed:15338056, ECO:0000269PubMed:17196963, ECO:0000269PubMed:20844015}.
Subcellular Localization Nucleus. Nucleus speckle.
Disease Associations
Tissue Specificity Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. {ECO:0000269PubMed:11356193}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
Cellular Component
GO:0000346 transcription export complex
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR003034 SAP domain
PFAM PF02037
PRINTS
PIRSF
SMART SM00513
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P82979
PhosphoSite PhosphoSite-P82979
TrEMBL
UniProt Splice Variant
Entrez Gene 84324
UniGene
RefSeq NP_149073
HUGO HGNC:24432
OMIM 610049
CCDS CCDS8892
HPRD 16716
IMGT
EMBL AF161434 AF486281 AJ409089 AK290508 BC007099 CH471054
GenPept AAF28994 AAH07099 AAM09686 BAF83197 CAC37950 EAW96838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca