InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAT10

Summary

InnateDB Protein

IDBP-39150.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAT10

Protein Name

N-acetyltransferase 10 (GCN5-related)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257829

InnateDB Gene

IDBG-39148 (NAT10)

Protein Structure

UniProt Annotation

Function

Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division. {ECO:0000269PubMed:14592445, ECO:0000269PubMed:17631499, ECO:0000269PubMed:18082603, ECO:0000269PubMed:19303003}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:14592445, ECO:0000269PubMed:19303003}. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	35 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008080	N-acetyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008150	biological_process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000182 GNAT domain
IPR007807 Helicase domain
IPR013562 Domain of unknown function DUF1726
IPR016181 Acyl-CoA N-acyltransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM