Version 5.4
Homo sapiens Protein: USP38
Summary
InnateDB Protein IDBP-39207.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP38
Protein Name ubiquitin specific peptidase 38
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000303434
InnateDB Gene IDBG-39205 (USP38)
Protein Structure
UniProt Annotation
Function Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains. {ECO:0000269PubMed:22689415}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle. Expressed in adrenal gland. {ECO:0000269PubMed:11572484, ECO:0000269PubMed:14715245}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NB14
PhosphoSite PhosphoSite-Q8NB14
TrEMBL B3KSB9
UniProt Splice Variant
Entrez Gene 84640
UniGene Hs.629273
RefSeq NP_115946
HUGO HGNC:20067
OMIM
CCDS CCDS3758
HPRD 15635
IMGT
EMBL AB067478 AC099549 AC116175 AF211481 AK057992 AK091712 AK093289 AK126943 AL833976 BC039115 BC068975 CH471056
GenPept AAH39115 AAH68975 AAK26248 BAB67784 BAB71627 BAC03730 BAG52681 BAG54405 CAD38820 EAX05075 EAX05076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca