InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MX2

Summary

InnateDB Protein

IDBP-3924.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MX2

Protein Name

myxovirus (influenza virus) resistance 2 (mouse)

Synonyms

MXB;

Species

Homo sapiens

Ensembl Protein

ENSP00000333657

InnateDB Gene

IDBG-3922 (MX2)

Protein Structure

UniProt Annotation

Function

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269PubMed:15184662, ECO:0000269PubMed:24048477, ECO:0000269PubMed:24055605, ECO:0000269PubMed:24121441}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15184662}. Nucleus {ECO:0000269PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006952	defense response
GO:0009615	response to virus
GO:0015031	protein transport
GO:0019221	cytokine-mediated signaling pathway
GO:0035455	response to interferon-alpha
GO:0045087	innate immune response (InnateDB)
GO:0046822	regulation of nucleocytoplasmic transport
GO:0051028	mRNA transport
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR001715 Calponin homology domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF00307
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00033
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt