InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRBP1

Summary

InnateDB Protein

IDBP-39246.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRBP1

Protein Name

nuclear receptor binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000233557

InnateDB Gene

IDBG-39242 (NRBP1)

Protein Structure

UniProt Annotation

Function

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269PubMed:11956649, ECO:0000269PubMed:15084397, ECO:0000303PubMed:11956649}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000269PubMed:11956649}. Endomembrane system {ECO:0000269PubMed:11956649}. Cell projection, lamellipodium {ECO:0000269PubMed:11956649}. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined with high levels in the testis. {ECO:0000269PubMed:10843813}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0008152	metabolic process
GO:0010467	gene expression

Cellular Component

GO:0005654	nucleoplasm
GO:0005938	cell cortex
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt