InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRG1

Summary

InnateDB Protein

IDBP-39303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRG1

Protein Name

immunoresponsive 1 homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366682

InnateDB Gene

IDBG-39301 (IRG1)

Protein Structure

UniProt Annotation

Function

Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269PubMed:23609450, ECO:0000269PubMed:23610393}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269PubMed:23609450, ECO:0000269PubMed:23610393}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047547	2-methylcitrate dehydratase activity
GO:0047613	aconitate decarboxylase activity

Biological Process

GO:0002760	positive regulation of antimicrobial humoral response
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007566	embryo implantation
GO:0008152	metabolic process
GO:0019543	propionate catabolic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0032496	response to lipopolysaccharide
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0035458	cellular response to interferon-beta
GO:0045824	negative regulation of innate immune response
GO:0050728	negative regulation of inflammatory response
GO:0071219	cellular response to molecule of bacterial origin
GO:0071222	cellular response to lipopolysaccharide
GO:0071346	cellular response to interferon-gamma
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071393	cellular response to progesterone stimulus
GO:0072573	tolerance induction to lipopolysaccharide
GO:2000379	positive regulation of reactive oxygen species metabolic process