InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKA

Summary

InnateDB Protein

IDBP-39399.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKA

Protein Name

diacylglycerol kinase, alpha 80kDa

Synonyms

DAGK; DAGK1; DGK-alpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000328405

InnateDB Gene

IDBG-39397 (DGKA)

Protein Structure

UniProt Annotation

Function

Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Subcellular Localization

Disease Associations

Tissue Specificity

Lymphocytes and oligodendroglial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

PFAM

PF00609
PF00781
PF00036
PF13202
PF13405
PF00130

PRINTS

PIRSF

SMART

SM00045
SM00046
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23743