InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WWP2

Summary

InnateDB Protein

IDBP-39540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WWP2

Protein Name

WW domain containing E3 ubiquitin protein ligase 2

Synonyms

AIP2; WWp2-like;

Species

Homo sapiens

Ensembl Protein

ENSP00000348283

InnateDB Gene

IDBG-39538 (WWP2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. {ECO:0000269PubMed:19274063, ECO:0000269PubMed:19651900}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19274063, ECO:0000269PubMed:20858735}.

Disease Associations

Tissue Specificity

Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. {ECO:0000269PubMed:19274063, ECO:0000269PubMed:9647693}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016874	ligase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006464	cellular protein modification process
GO:0010629	negative regulation of gene expression
GO:0016567	protein ubiquitination
GO:0032410	negative regulation of transporter activity
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046718	viral entry into host cell
GO:0051224	negative regulation of protein transport
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:1901016	regulation of potassium ion transmembrane transporter activity