Version 5.4
Homo sapiens Protein: NR2C2AP
Summary
InnateDB Protein IDBP-39599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR2C2AP
Protein Name nuclear receptor 2C2-associated protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332823
InnateDB Gene IDBG-39597 (NR2C2AP)
Protein Structure
UniProt Annotation
Function May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269PubMed:12486131}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12486131}.
Disease Associations
Tissue Specificity Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas. {ECO:0000269PubMed:12486131}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007155 cell adhesion
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR008979 Galactose-binding domain-like
PFAM PF00754
PRINTS
PIRSF
SMART SM00231
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86WQ0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 126382
UniGene Hs.708153
RefSeq NP_795361
HUGO HGNC:30763
OMIM 608719
CCDS CCDS32967
HPRD 16376
IMGT
EMBL AC003110 AY101377 BC057837
GenPept AAH57837 AAM48286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca