InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPCS1

Summary

InnateDB Protein

IDBP-39621.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPCS1

Protein Name

signal peptidase complex subunit 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000233025

InnateDB Gene

IDBG-39619 (SPCS1)

Protein Structure

UniProt Annotation

Function

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

Subcellular Localization

Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006412	translation
GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005787	signal peptidase complex
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane