InnateDB Protein
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IDBP-39630.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBM28
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Protein Name
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RNA binding motif protein 28
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000223073
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InnateDB Gene
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IDBG-39628 (RBM28)
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Protein Structure
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Function |
Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269PubMed:17081119}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:17081119, ECO:0000269Ref.7}.
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Disease Associations |
Alopecia, neurologic defects, and endocrinopathy syndrome (ANES) [MIM:612079]: Affected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair. All have moderate to severe mental retardation, progressive motor deterioration and central hypogonadotropic hypogonadism with delayed or absent puberty and central adrenal insufficiency. Additional features included short stature, microcephaly, gynecomastia, pigmentary anomalies, hypodontia, kyphoscoliosis, ulnar deviation of the hands, and loss of subcutaneous fat. {ECO:0000269PubMed:18439547}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:18439547}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NW13
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PhosphoSite |
PhosphoSite-Q9NW13
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TrEMBL |
A0A024R753
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UniProt Splice Variant |
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Entrez Gene |
55131
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UniGene |
Hs.274263
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RefSeq |
NP_060547
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HUGO |
HGNC:21863
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OMIM |
612074
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CCDS |
CCDS5801
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HPRD |
07668
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IMGT |
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EMBL |
AC010655
AC018635
AK001239
AK222716
AK300500
BC013889
CH236947
CH471070
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GenPept |
AAH13889
BAA91575
BAD96436
BAG62214
EAL24314
EAW83643
EAW83644
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