InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC12A2

Summary

InnateDB Protein

IDBP-39696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC12A2

Protein Name

solute carrier family 12 (sodium/potassium/chloride transporters), member 2

Synonyms

BSC; BSC2; NKCC1; PPP1R141;

Species

Homo sapiens

Ensembl Protein

ENSP00000262461

InnateDB Gene

IDBG-39694 (SLC12A2)

Protein Structure

UniProt Annotation

Function

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in many tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008511	sodium:potassium:chloride symporter activity
GO:0008519	ammonium transmembrane transporter activity
GO:0015377	cation:chloride symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006821	chloride transport
GO:0006972	hyperosmotic response
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0015696	ammonium transport
GO:0030321	transepithelial chloride transport
GO:0035264	multicellular organism growth
GO:0045795	positive regulation of cell volume
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0055085	transmembrane transport
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0070634	transepithelial ammonium transport
GO:0072488	ammonium transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002443 Na/K/Cl co-transporter
IPR002444 Na/K/Cl co-transporter 1
IPR004841 Amino acid permease/ SLC12A domain
IPR004842 Na/K/Cl co-transporter superfamily
IPR013612 Amino acid permease, N-terminal

PFAM

PF00324
PF08403

PRINTS

PR01207
PR01208

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55011