Version 5.4
Homo sapiens Protein: SLC12A2
Summary
InnateDB Protein IDBP-39700.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC12A2
Protein Name solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Synonyms BSC; BSC2; NKCC1; PPP1R141;
Species Homo sapiens
Ensembl Protein ENSP00000340878
InnateDB Gene IDBG-39694 (SLC12A2)
Protein Structure
UniProt Annotation
Function Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in many tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008519 ammonium transmembrane transporter activity
GO:0015377 cation:chloride symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0015696 ammonium transport
GO:0030321 transepithelial chloride transport
GO:0055085 transmembrane transport
GO:0070634 transepithelial ammonium transport
GO:0072488 ammonium transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002443 Na/K/Cl co-transporter
IPR002444 Na/K/Cl co-transporter 1
IPR004841 Amino acid permease/ SLC12A domain
IPR004842 Na/K/Cl co-transporter superfamily
IPR013612 Amino acid permease, N-terminal
PFAM PF00324
PF08403
PRINTS PR01207
PR01208
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P55011
PhosphoSite PhosphoSite-P55011
TrEMBL
UniProt Splice Variant
Entrez Gene 6558
UniGene Hs.713135
RefSeq NP_001243390
HUGO HGNC:10911
OMIM 600840
CCDS CCDS58965
HPRD 06775
IMGT
EMBL AF439152 U30246
GenPept AAC50561 AAL32454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca