InnateDB Protein
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IDBP-39806.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HILPDA
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Protein Name
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chromosome 7 open reading frame 68
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000257696
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InnateDB Gene
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IDBG-39804 (HILPDA)
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Protein Structure
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Function |
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. {ECO:0000269PubMed:15930302, ECO:0000269PubMed:20624928}.
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Subcellular Localization |
Lipid droplet. Secreted. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level). {ECO:0000269PubMed:15930302, ECO:0000269PubMed:20624928, ECO:0000269PubMed:21614900}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y5L2
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PhosphoSite |
PhosphoSite-Q9Y5L2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
29923
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UniGene |
Hs.706124
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RefSeq |
NP_037464
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HUGO |
HGNC:28859
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OMIM |
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CCDS |
CCDS5802
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HPRD |
17105
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IMGT |
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EMBL |
AF144755
AK222583
BC001863
BC093742
BC112183
CH236947
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GenPept |
AAD37585
AAH01863
AAH93742
AAI12184
BAD96303
EAL24309
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