InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RIPK4

Summary

InnateDB Protein

IDBP-3986.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RIPK4

Protein Name

receptor-interacting serine-threonine kinase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000332454

InnateDB Gene

IDBG-3982 (RIPK4)

Protein Structure

UniProt Annotation

Function

Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. {ECO:0000269PubMed:12446564, ECO:0000269PubMed:22197488}.

Subcellular Localization

Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Popliteal pterygium syndrome, lethal type (PPS-L) [MIM:263650]: An autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia. Early lethality is common, although survival into childhood and beyond has been reported. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0006468	protein phosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00069
PF07714
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00109
PR01415

PIRSF

SMART

SM00248
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt